U.S. opioid overdose death rate from 1999 to 2022
In 2022, the death rate from opioid overdose was 25 per 100,000 population. Opioids are the main driver of overdose deaths in the United States. This statistic presents the death rate from opioid overdose in the U.S. from 1999 to 2022, per 100,000 population.