Unlike in the two years before, COVID-19 vaccine Comirnaty did not maintain its place as the global top ranked pharmaceutical product based on revenue. Merck's cancer drug Keytruda is the new best-selling drug worldwide, with some 25 billion U.S. dollars of revenue. Humira came in as third ranked drug in 2023, with revenues totaling 14.4 billion dollars.
Humira
Humira is used mostly for the treatment of rheumatoid and psoriatic arthritis. However, like many other top drugs, the range of medical conditions it can be used to treat is much larger. Thus, the drug is also used to treat Crohn’s disease, ankylosing spondylitis, ulcerative colitis, psoriasis, uveitis, and some other autoimmune diseases. Humira is administered subcutaneously via injection. It was approved for the first time in 2002 in the United States.
Blockbuster drug reliance
Blockbuster drugs often have a large impact on the manufacturer. In some cases, pharmaceutical companies are highly dependent on their sales performance. In the case of Humira, AbbVie generates over 36 percent of its total revenue from this drug and over 53 percent from its top three products. Companies that depend on a small number of blockbuster drugs could be under threat of heavy revenue loss. Biosimilars of Humira (adalimumab) are already available and will take more and more of the market in the years to come. However, Humira has exceeded the 20 billion-dollar-revenue mark in contrast to some predictions made years ago.
Leading pharmaceutical products by sales worldwide in 2023
(in billion U.S. dollars)
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Website (drugdiscoverytrends.com). (March 27, 2024). Leading pharmaceutical products by sales worldwide in 2023 (in billion U.S. dollars) [Graph]. In Statista. Retrieved December 23, 2024, from https://www.statista.com/statistics/258022/top-10-pharmaceutical-products-by-global-sales-2011/
Website (drugdiscoverytrends.com). "Leading pharmaceutical products by sales worldwide in 2023 (in billion U.S. dollars)." Chart. March 27, 2024. Statista. Accessed December 23, 2024. https://www.statista.com/statistics/258022/top-10-pharmaceutical-products-by-global-sales-2011/
Website (drugdiscoverytrends.com). (2024). Leading pharmaceutical products by sales worldwide in 2023 (in billion U.S. dollars). Statista. Statista Inc.. Accessed: December 23, 2024. https://www.statista.com/statistics/258022/top-10-pharmaceutical-products-by-global-sales-2011/
Website (drugdiscoverytrends.com). "Leading Pharmaceutical Products by Sales Worldwide in 2023 (in Billion U.S. Dollars)." Statista, Statista Inc., 27 Mar 2024, https://www.statista.com/statistics/258022/top-10-pharmaceutical-products-by-global-sales-2011/
Website (drugdiscoverytrends.com), Leading pharmaceutical products by sales worldwide in 2023 (in billion U.S. dollars) Statista, https://www.statista.com/statistics/258022/top-10-pharmaceutical-products-by-global-sales-2011/ (last visited December 23, 2024)
Leading pharmaceutical products by sales worldwide in 2023 (in billion U.S. dollars) [Graph], Website (drugdiscoverytrends.com), March 27, 2024. [Online]. Available: https://www.statista.com/statistics/258022/top-10-pharmaceutical-products-by-global-sales-2011/