Rate of birth defects U.S.

In the period 2016-2020, considering the following birth defects, clubfoot was the most common birth defect among babies born in the United States, with almost 19 babies born with this defect per 10,000 live births. Clubfoot is a birth defect in which a baby's foot or feet are turned inward. This statistic shows the rate of select birth defects in the United States from 2016 to 2020.

Rate of select birth defects in the United States from 2016 to 2020 (per 10,000 live births)

Characteristic	Rate per 10,000 live births
Clubfoot	18.65
Trisomy 21 (Down syndrome)	15.55
Pulmonary valve atresia and stenosis	10.29
Cleft lip with and without cleft palate	9.69
Cleft lip with cleft palate	6.32
Cleft palate alone	6.32
Atrioventricular septal defect (Endocardial cushion defect)	5.84
Coarctation of the aorta	5.84
Limb deficiencies (reduction defects)	4.84
Tetralogy of Fallot (TOF)	4.81
Rectal and large intestinal atresia/stenosis	4.5
Gastroschisis	4.1
Spina bifida without anencephaly	3.48
Cleft lip alone	3.38
Diaphragmatic hernia	3.11
Trisomy 18	3
Transposition of the great arteries (TGA)	2.99
Hypoplastic left heart syndrome	2.53
Dextro-transposition of great arteries(d-TGA)	2.53
Omphalocele	2.49
Esophageal atresia/tracheoesophageal fistula	2.4
Double outlet right ventricle (DORV)	2.36
Anophthalmia/microphthalmia	1.97
Anencephaly	1.91
Tricuspid valve atresia and stenosis	1.81
Pulmonary valve atresia	1.49
Trisomy 13	1.44
Total anomalous pulmonary venous connection (TAPVC)	1.32
Interrupted aortic arch (IAA)	0.99
Encephalocele	0.95
Tricuspid valve atresia	0.88
Ebstein anomaly	0.77
Single Ventricle	0.65
Common truncus (truncus arteriosus or TA)	0.63

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Release date

January 2024

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Region

United States

Survey time period

2016 to 2020

Supplementary notes

Note from the original source: "Program inclusion criteria: Programs that used active case-finding or a combination of active and passive case-finding for their methodology. Programs had to collect all outcomes of pregnancy to be included. Birth defect surveillance programs and delivery years that are included in the current analysis: California (10 counties), Delaware, Hawaii (2016–2017), Iowa, Massachusetts, Metropolitan Atlanta (3 counties), North Carolina, Oklahoma, Puerto Rico, Rhode Island, South Carolina, Texas (2016–2019), and Utah."

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