Rate of chromosome (gene) malformation birth defects by age U.S.

In the period 2016-2020, babies born to women aged 40 years and older in the United States had the highest rates of Down syndrome, with around 121 babies born with this defect per 10,000 live births. Down syndrome is a genetic condition that can affect how the brain and body develop and is the most common chromosomal condition in the United States. This statistic shows the rate of select chromosome (gene) malformation birth defects in the United States from 2016 to 2020, by age.

Rate of select chromosome (gene) malformation birth defects in the United States from 2016 to 2020, by age (per 10,000 live births)

Characteristic	Trisomy 13	Trisomy 18	Trisomy 21 (Down syndrome)
Less than 20 years	0.66	1.2	7.64
20 to 24 years	0.96	1.27	6.42
25 to 29 years	0.85	1.56	7.7
30 to 34 years	1.4	2.34	12.37
35 to 39 years	3.03	7.16	38.98
40 years and older	8.58	28.59	120.74
Total	1.55	3.27	16.33

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Release date

January 2024

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Region

United States

Survey time period

2016 to 2020

Supplementary notes

Note from the original source: "This paper presents national population-based birth defects prevalence estimates for the period of 2016–2020. In March of 2023, the National Birth Defects Prevention Network (NBDPN) distributed a call for data to all US-based birth defects surveillance programs. Of the programs that responded to the call for data, we limited our analysis to 13 programs that used active or a combination of active plus passive case ascertainment methods and ascertained all birth outcomes (live births, fetal deaths, and terminations): California (10 counties), Delaware, Hawaii (2016–2017 only), Iowa, Massachusetts, metropolitan Atlanta (3 counties), North Carolina, Oklahoma, Puerto Rico, Rhode Island, South Carolina, Texas (2016–2019 only), and Utah."

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