Number of annual cases of select chromosome birth defects in the U.S. as of 2024

As of 2024, around 5,713 babies born each year in the United States had trisomy 21, more commonly known as Down syndrome. Down syndrome is a genetic condition that can affect how the brain and body develop and is the most common chromosomal condition in the United States. This statistic shows the number of babies affected each year by select chromosome (gene) malformation birth defects in the United States as of 2024.