As of December 12, 2021, a total of 6,409 cases of pyrexia (fever) had been reported in Spain after receiving the vaccine against COVID-19 developed by Oxford and AstraZeneca. Similarly to the adverse events recorded with the Pfizer/BioNTech vaccine, pyrexia was on top of the list, followed by headache and myalgia, which reached around 4.7 thousand and 2.9 thousand cases. As of that date, more than 9.7 million Vaxzevria (AstraZeneca) vaccines had been used in the European country.
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Most common adverse events reported after receiving the AstraZeneca (Vaxzevria) vaccine against COVID-19 in Spain as of December 12, 2021
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Includes any kind of adverse event notified after receiving the coronavirus (COVID-19) vaccine. Adverse events are not to be interpreted as induced by the vaccine until a casual relationship is confirmed.
As of December 12, 2021 a total of 9,791,385 doses of the Oxford-AstraZeneca vaccine had been administered in Spain.
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AEMPS. (December 20, 2021). Most common adverse events reported after receiving the AstraZeneca (Vaxzevria) vaccine against COVID-19 in Spain as of December 12, 2021 [Graph]. In Statista. Retrieved August 13, 2025, from https://www.statista.com/statistics/1220418/oxford-astrazeneca-vaccine-most-common-adverse-events-reported-in-spain/
AEMPS. "Most common adverse events reported after receiving the AstraZeneca (Vaxzevria) vaccine against COVID-19 in Spain as of December 12, 2021." Chart. December 20, 2021. Statista. Accessed August 13, 2025. https://www.statista.com/statistics/1220418/oxford-astrazeneca-vaccine-most-common-adverse-events-reported-in-spain/
AEMPS. (2021). Most common adverse events reported after receiving the AstraZeneca (Vaxzevria) vaccine against COVID-19 in Spain as of December 12, 2021. Statista. Statista Inc.. Accessed: August 13, 2025. https://www.statista.com/statistics/1220418/oxford-astrazeneca-vaccine-most-common-adverse-events-reported-in-spain/
AEMPS. "Most Common Adverse Events Reported after Receiving The Astrazeneca (Vaxzevria) Vaccine against Covid-19 in Spain as of December 12, 2021." Statista, Statista Inc., 20 Dec 2021, https://www.statista.com/statistics/1220418/oxford-astrazeneca-vaccine-most-common-adverse-events-reported-in-spain/
AEMPS, Most common adverse events reported after receiving the AstraZeneca (Vaxzevria) vaccine against COVID-19 in Spain as of December 12, 2021 Statista, https://www.statista.com/statistics/1220418/oxford-astrazeneca-vaccine-most-common-adverse-events-reported-in-spain/ (last visited August 13, 2025)
Most common adverse events reported after receiving the AstraZeneca (Vaxzevria) vaccine against COVID-19 in Spain as of December 12, 2021 [Graph], AEMPS, December 20, 2021. [Online]. Available: https://www.statista.com/statistics/1220418/oxford-astrazeneca-vaccine-most-common-adverse-events-reported-in-spain/
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