Rate of transfusion-associated adverse reactions by type U.S. 2021

In 2021, there were an estimated 274 blood transfusion-associated adverse reactions in the United States that required any diagnostic or therapeutic intervention per 100,000 components transfused. This graph shows the estimated rate of blood transfusion-associated adverse reactions in the United States in 2019 and 2021, by type, per 100,000 components transfused.

Rate of blood transfusion-associated adverse reactions in the United States in 2019 and 2021, by type (per 100,000 components transfused)

Characteristic	2019	2021
Total number of reactions that required any diagnostic or therapeutic intervention*	293.7	273.8
Febrile, nonhemolytic transfusion reaction	119.1	113.3
Mild to moderate allergic reactions	81.5	71.4
Delayed serologic transfusion reaction	19	22.2
Transfusion-associated circulatory overload	13.4	14.7
Hypotensive transfusion reaction	8.7	7.8
Transfusion-associated dyspnea	7	5.5
Delayed hemolytic transfusion reaction	4.1	4.6
Severe allergic reactions	2.7	2.5
Acute hemolytic transfusion reaction (other antibodies)	1	1.4
Transfusion-related acute lung injury	1.5	1.1
Posttransfusion purpura	0.63	0.57
Acute hemolytic transfusion reaction (ABO)	0.33	0.37
Transfusion-transmitted bacterial infection (previously asked as posttransfusion sepsis)	0.35	0.34
Transfusion-transmitted viral infection	0.02	0.06
Transfusion-transmitted parasitic infection	0.02	0.02
Reactions that were life threatening, requiring major medical intervention**	2.7	0.98

Loading statistic...

Download

Source

Show detailed source information?

Already a member?

Sources

Use Ask Statista Research Service

Release date

September 2023

More information

Region

United States

Survey time period

2019 and 2021

Method of interview

Online omnibus survey

Supplementary notes

Data is from the National Blood Collection and Utilization Survey (NBCUS).
* Diagnostic tests were defined as “any test to confirm a reaction occurred” and therapeutic intervention was defined as “intervention to treat a reaction (e.g., vasopressors, intubation, transfer to intensive care to prevent impairment, permanent damage, or death).
** For example, vasopressors, blood pressure support, intubation, or transfer to the intensive care unit.

Citation formats